货号：AB5908-200UL

品牌：Merck Millipore

规格：200UL

目录价：￥10000.00

市场价格：￥8500.00

会员价格：￥8000.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel HERG Antibody, C-terminus | AB5908-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes HERG (hKv11.1, Voltage gated K+ channel subfamily H member 2, KCNH2, ether-a-go-go related channel). The antibody recognizes the HERG1b splice variant but not splice variants HERG1-3 or HERG-4. The immunogen shares similiarity with rat erg2 (22/54) and rat erg3 (21/54). View All» Molecular Weight: 127 kDa View All» Epitope: C-terminus View All» Immunogen: GST fusion protein corresponding to amino acids 1106-1159 of human erg1 (HERG) (Accession number Q12809). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:200-400 using ECL on HERG transfected HEK293 cells. Immunocytochemistry Immunoprecipitation Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 120 μg of fusion protein (35 kD). The stock solution of the antigen can be made up using 100 μL of PBS. For negative control, preincubate 3 μg of fusion protein with 1 μg of antibody for one hour at room temperature. For positive control, use 20 ng of fusion protein per lane. Optimal concentrations must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q12809 View All» Entrez Gene Number:

• NM_000238.2

• NM_172056.1

• NM_172057.1
  View All» Gene Symbol:
  • KCNH2

  • ERG1

  • LQT2

  • erg1

  • HERG

  • SQT1

  • H-ERG

  • Kv11.1

  • HERG1

  • Erg1

  • ERG
    View All» Alternate Names: Erg1; Kcnh2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. View All» UniProt Summary: FUNCTION: SwissProt: Q12809 # Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.SIZE: 1159 amino acids; 126655 Da SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Highly expressed in heart and brain.DOMAIN:SwissProt: Q12809 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.PTM: Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.DISEASE: SwissProt: Q12809 # Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:152427]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. & Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.SIMILARITY: Belongs to the potassium channel family. H (Eag) subfamily. & Contains 1 cyclic nucleotide-binding domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 1 PAS (PER-ARNT-SIM) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Potassium Channel HERG Antibody, C-terminus | AB5908-200UL View All» Concentration: 0.6 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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