货号：AB5926

品牌：Merck Millipore

规格：EA

目录价：￥3890.00

市场价格：￥3306.50

会员价格：￥3112.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel Kv1.4 Antibody | AB5926 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Kv1.4 View All» Immunogen: Synthetic peptide corresponding to the N-terminus of rat Kv1.4. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunoblotting Immunocytochemistry Immunohistochemistry on 4% paraformaldehyde fixed tissues. Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Presentation: Liquid. Buffer = 0.1M Phosphate buffer saline, pH 7.4. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P22459 View All» Entrez Gene Number: NM_002233.2 View All» Gene Symbol:
  • KCNA4

  • HPCN2

  • KV1.4

  • HBK4

  • PCN2

  • HUKII

  • Kv1.4

  • KCNA4L

  • KCNA8

  • HK1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. View All» UniProt Summary: FUNCTION: SwissProt: P22459 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.SIZE: 653 amino acids; 73288 Da SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with OPRS1 (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DOMAIN: SwissProt: P22459 The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. & The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Potassium Channel Kv1.4 Antibody | AB5926 View All» Concentration: 3.1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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