货号：AB5934

品牌：Merck Millipore

规格：

目录价：￥4567.00

市场价格：￥3881.95

会员价格：￥3653.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sox1 Antibody | AB5934 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody recognizes SOX1 near the N-terminus. View All» Molecular Weight: ~39 kDa observed. An uncharacterized band may appear at ~110 kDa in some lysates. View All» Epitope: Near N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human SOX1 near the N-terminus. View All» Background Information: Sox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling. SOX1, therefore, defines the dividing neural precursors of the embryonic central nervous system. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse, Human, and Rat. Predicted to react with Rhesus Monkey based on 100% sequence homology. View All» Control: Mouse neuronal stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse neuronal stem cell lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected SOX1 on 10 µg of mouse neuronal stem cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified chicken IgY in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00570 View All» Entrez Gene Number: NP_005977 View All» Gene Symbol: SOX1 View All» Alternate Names: Transcription factor SOX-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. View All» UniProt Summary: FUNCTION: Transcriptional activator (By similarity).SIZE: 387 amino acids; 38856 Da SUBCELLULAR LOCATION: Nucleus (Probable).TISSUE SPECIFICITY: Mainly in the developing central nervous system.SIMILARITY: Contains 1 HMG box DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-SOX1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Chicken View All»
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