货号：AB5935

品牌：Merck Millipore

规格：100UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40 | AB5935 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Tyrosine Hydroxylase, phosphoSer40. The antibody recognizes a protein of 60 kDa corresponding to TH phosphorylated at Ser40. Depending on brain region being studied, protein loads and detection methods used some higher molecular weight bands may be detected. View All» Molecular Weight: 60 kDa View All» Epitope: phospho-Ser40 View All» Immunogen: Synthetic peptide from the phosphoSer40 of rat Tyrosine Hydroxylase. View All» Modifications: Phosphorylation View All» Background Information: Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. View All» Species Reactivity:

• Rat

• Mouse

• Human

• Avian
  View All» Species Reactivity Note: Rat and mouse. It is expected that the antibody will also react with human, porcine, quail and non-human primates due to sequence homology (100%). Other species have not been tested. View All» Application Notes: Immunohistochemistry: A 1:1,000 dilution of a previous lot was used in IH.Immunocytochemistry: A 1:1,000 dilution of a previous lot was used in IC.Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: brain (sympathetic nerve terminals) and adrenal glands. View All» Quality Assurance: Routinely evaluated by Western Blot on PC12 lysates.Western Blot Analysis: 1:500 dilution of this lot detected TYROSINE HYDROX PSER40 on 10 μg of PC12 lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal liquid in buffer containing 10mM Hepes, pH 7.5, 150mM NaCl, 100 µg/mL BSA, and 50% glycerol. View All» Storage Conditions: Stable for 6 months at -20°C in undiluted from date of receipt. View All» UniProt Number: P07101 View All» Entrez Gene Number: NM_000360.3 View All» Gene Symbol:
  • TH

  • TYH

  • EC 1.14.16.2
    View All» Alternate Names: Tyrosine Monooxygenase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. View All» UniProt Summary: FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.COFACTOR: Fe(2+) ion.SIZE: 528 amino acids; 58524 Da TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40 | AB5935 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Cytoplasmic View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-158265.htm
      © Merck Millipore代理AB5935 Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40;store at -20℃，产品报价联系微信jinshanbio