货号：AB5937

品牌：Merck Millipore

规格：

目录价：￥3574.00

市场价格：￥3037.90

会员价格：￥2859.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ubiquitin Carboxyl-Terminal Hydrolase L1 Antibody, a.a. 61-78 of hUCH-L1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1). By Western blot the antibody labels a 27 kDa protein. View All» Epitope: a.a. 61-78 of hUCH-L1 View All» Immunogen: Synthetic peptide {NFRKKQIEELKGQEVSPK} from human UCH-L1. View All» Background Information: Ubiquitin carboxyl-terminal hydrolase L1 (UCH μL1) is one of the most abundant proteins in the brain and represents 1-2% of total soluble brain proteins. UCH-L1 activity is thought to cleave polymeric ubiquitin to monomers and to hydrolyze bonds between ubiquitin-protein conjugatges to regenerate ubiquitin monomers. In many degenerative diseases, ubiquitin has been identified as a component of several inclusion bodies and certain of these are associated with UCH-L1 activity. One such inclusion is the Lewy body of Parkinson's disease. Since a polymorphism has been detected in the UCH-L1 gene, it is suspected to have a role is some forms of Parkinson's disease. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1,000-1:2,000; reacts with a 27kDa protein. ELISA against immunogen peptide: > 1:71,350 Optimal working dilutions must be determined by the end user. View All» Presentation: Goat serum. Liquid containing 0.01% thimerosal. View All» Storage Conditions: Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer. View All» UniProt Number: P09936 View All» Entrez Gene Number: NM_004181.3 View All» Gene Symbol:

• UCHL1

• PARK5

• UCH-L1

• Uch-L1

• PGP9.5

• EC 3.4.19.12

• EC 6.-.-.-
  View All» Alternate Names: UCH-L1;PGP 9.5;PARK5; Ubiquitin C-terminal Esterase L1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P09936 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.SIZE: 223 amino acids; 24824 Da SUBUNIT: Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary.PTM: O-glycosylated (By similarity).DISEASE: SwissProt: P09936 # Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.SIMILARITY: SwissProt: P09936 ## Belongs to the peptidase C12 family.MISCELLANEOUS: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8. View All» Brand Family: Chemicon View All» Product Name: Anti-Ubiquitin Carboxyl-Terminal Hydrolase L1 Antibody, a.a. 61-78 of hUCH-L1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Goat View All»
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