货号：AB5977

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Musashi-1 Antibody | AB5977 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Musashi-1. View All» Molecular Weight: 39 kDa View All» Immunogen: Synthetic peptide, amino acids 5-21 of Musashi. View All» Background Information: In mammals, the Musashi family is important for cell fate determination, playing roles in maintenance of the stem-cell state, differentiation and tumorigenesis. Musashi1 (also known as Msi1), is selectivley expressed in neural progenitor cells, including neural stem cells. Outside the nervous system, Musashi1 is a selective marker for intestinal stem or early lineage cells. Musashi1 interacts with the Notch pathway during asymmetric cell division by binding the 3' UTR of Numb. Numb is prevented from repressing Notch signaling when Musashi1 is present. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and rodent. Reactivity with other species has not been confirmed. View All» Application Notes: Immunohistochemistry: 1:200-1:1,000 dilution from a previous lot was used.Immunocytochemistry: 1:200-1:1,000 dilution from a previous lot was used.Western blot: 1:200-1:1,000 using ECL.Optimal working dilutions must be determined by the end user. View All» Control: Mouse cortical neural stem cells (Catalog No. SCR029). View All» Quality Assurance: Routinely evaluated by Western Blot on Human Placenta lysates.Western Blot Analysis: 1:1000 dilution of this lot detected Musashi-1 on 10 μg of Human placenta lysates. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives. View All» Storage Conditions: Stable for 1 year at -80ºC from date of receipt. View All» UniProt Number: O43347 View All» Entrez Gene Number: NM_002442.2 View All» Gene Symbol:
  • MSI1

  • Musashi-1
    View All» Alternate Names: Musashi homolog 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. View All» UniProt Summary: FUNCTION: SwissProt: O43347 # RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).SIZE: 362 amino acids; 39125 Da SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).TISSUE SPECIFICITY: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.DOMAIN: SwissProt: O43347 The first RNA recognition motif binds more strongly to RNA compared to the second one (By similarity).SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Musashi-1 Antibody | AB5977 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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