货号：AB6005

品牌：Merck Millipore

规格：

目录价：￥4563.00

市场价格：￥3878.55

会员价格：￥3650.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MT1-MMP Antibody, catalytic domain | AB6005 View All» Replaces: AB8102 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes MT1-MMP (MMP-14). View All» Molecular Weight: ~ 65 kDa View All» Epitope: Catalytic domain View All» Immunogen: GST-tagged recombinant protein corresponding to the catalytic domain of human MT1-MMP. View All» Background Information: Matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes degrade components of extracellular matrix (ECM), including collagens, fibronectin, laminin and other glycoproteins. MMPs play an important role in wound healing, apoptosis, development, angiogenesis, cancer metastases, and tissue remodeling. Most MMPs are secreted as inactive proproteins which are cleaved and activated; however, MT1-MMP (MMP-14) is a member of the membrane-type subfamily. Each member of this subfamily has a transmembrane domain suggesting these proteins are expressed at the cell’s surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of ECM components and thought to be an important tool for cellular remodeling of the ECM. It is also involved in endothelial cell migration, and although not fully characterized, MT1-MMP activity appears to modulate endothelial invasion, and formation of capillary tubes during angiogenesis (Galvez, 2001). It also appears to be a factor in monocyte recruitment during inflammation (Matias-Roman, 2005). MT1-MMP also activates MMP-2 protein, an activity involved in tumor invasion. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee based on 100% sequence homology.Equine, sheep, porcine, canine, and bovine (99% sequence homology). Mouse and rat (97% sequence homology). Orangutan (92% sequence homology). View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a previous lot detected MT1-MMP in 10 µg of human normal uterus tissue lysate.Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected MT1-MMP in prostate carcinoma tissue.Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated MT1-MMP from 500 µg of human normal uterus RIPA lysate. View All» Control: HT-1080 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HT-1080 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected MT1-MMP in 10 µg of HT-1080 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P50281 View All» Entrez Gene Number: NP_004986.1 View All» Gene Symbol:
  • MMP14

  • MTMMP1

  • MMP-14

  • MT1MMP

  • MT1-MMP

  • MMP-X1
    View All» Alternate Names:
    • MT1MMP

    • MMP-14

    • MMP14

    • Membrane-type-1 matrix metalloproteinase

    • Membrane-type matrix metalloproteinase 1

    • matrix metalloproteinase 14 (membrane-inserted)

    • matrix metallopeptidase 14 (membrane-inserted)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.COFACTOR: Binds 1 zinc ion per subunit (by similarity). & Calcium (by similarity).SIZE: 582 amino acids; 65884 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.TISSUE SPECIFICITY: In stromal cells of colon, breast, and head and neck.DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Product Name: Anti-MT1-MMP, catalytic domain View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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