货号：AB6012

品牌：Merck Millipore

规格：EA

目录价：￥3708.00

市场价格：￥3151.80

会员价格：￥2966.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-7 (N-terminus) Antibody | AB6012 View All» Replaces: AB8118 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes the N-terminus of human MMP-7. View All» Molecular Weight: ~28 kDa observed. Band representative of the zymogen form of MMP-7. An 18 kDa band (active form) may be detected in certain samples. View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human MMP-7. View All» Background Information: Degradation of the extracellular matrix (ECM) is an essential step in tumor invasion and metastasis. MMPs each have different substrate specificities within the ECM and are important in its degradation. MMP activity is dependent on the levels of activated MMP and tissue inhibitors of matrix metalloproteinases (TIMPs). The matrix metalloproteinase, matrilysin, is thought to play an important role in the early steps of tumor progression. Expression of MMP2, -7, and -11 is greater in pancreatic carcinoma than in normal pancreas. View All» Species Reactivity:

• Human

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with rhesus macaque based on 100% sequence homology. Mouse (69.2%). Rat (61.5%). View All» Control: Concentrated conditioned media from PMA-treated HL-60 cells. View All» Quality Assurance: Evaluated by Western blot in concentrated conditioned media from PMA-treated HL-60 cells.Western blot Analysis: 1 µg/ml of antibody detected MMP-7 on 10 µg of concentrated conditioned media from PMA-treated HL-60 cells.cells. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P09237 View All» Entrez Gene Number: NP_002414 View All» Gene Symbol:
  • MMP7

  • MMP-7

  • MPSL1

  • Matrin

  • PUMP-1

  • PUMP1

  • matrin
    View All» Alternate Names:
    • Matrix metalloproteinase-7

    • PUMP

    • Pump-1 protease

    • Uterine metalloproteinase

    • matrilysin

    • matrix metallopeptidase 7
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 267 amino acids; 29677 Da DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. View All» Product Name: Anti-MMP-7 (N-terminus) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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