货号：AB6021

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Stabilin-1 Antibody, C-terminus | AB6021 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes the C-terminus of Stabilin-1 within the cytoplasmic region of a cell. View All» Molecular Weight: ~ 275 kDa View All» Epitope: C-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the C-terminus of human Stabilin-1. View All» Background Information: Stabilin-1 and Stabilin-2 constitute a novel family of fasciclin domain-containing hyaluronan receptor homologs that may play a role in cell-cell and cell-extracellular matrix interactions in vascular function and inflammatory processes. Stabilin-1 is a transmembrane protein, expressed in endothelial cells within the sinusoidal regions of liver, spleen, and lymph tissues as well as macrophages. Stabilin-2 is absent from the latter (Politz, 2002). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Other notable species homologies include mouse (87%) and rat (83%). View All» Application Notes: Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Stabilin-1 in human placental tertiary villi.Immunofluorescence Analysis: A previous lot of Anti-Stabilin-1, C-terminus was shown to positively stain using immunofluorescence techniques (Kzhyshkowska, 2008). View All» Control: HUVEC lysate. View All» Quality Assurance: Evaluated by Western blot in HUVEC lysate.Western blot Analysis: 1:1,000 dilution of this antibody detected Stabilin-1 on 10 µg of HUVEC lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal in serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt if stored in undiluted aliquots. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9NY15 View All» Entrez Gene Number: Q9NY15 View All» Gene Symbol:

• CLEVER-1

• FEEL-1

• FEEL1

• FELE-1

• FEX1

• KIAA0246

• STAB-1
  View All» Alternate Names:
  • Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1

  • MS-1 antigen

  • common lymphatic endothelial and vascular endothelial receptor-1

  • fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1

  • stabilin 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)

    • Immunofluorescence
      View All» UniProt Summary: FUNCTION: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. SUBUNIT STRUCTURE: Interacts with CHID1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential. TISSUE SPECIFICITY: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells. SEQUENCE SIMILARITIES: Contains 16 EGF-like domains.Contains 7 FAS1 domains.Contains 2 laminin EGF-like domains.Contains 1 Link domain. View All» Product Name: Anti-Stabilin-1, C-terminus View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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