货号：AB6041

品牌：Merck Millipore

规格：EA

目录价：￥3708.00

市场价格：￥3151.80

会员价格：￥2966.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-POM121 Antibody | AB6041 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes POM121. View All» Molecular Weight: Calculated MW 121; Observed MW ~ 145 - 150 kDa . The MW difference is documented in publication (Hallberg, 1993). View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to mouse POM121. View All» Isotype: IgG View All» Background Information: At the conclusion of mitosis, nuclear assembly is a process that establishes cell compartmentalization. Data have shown there are several novel molecular regulators of this membrane-shaping process. A major conclusion from these studies is that the nuclear envelope (NE) is the result of a massive reorganization of the tubular endoplasmic reticulum (ER) network on chromatin. Transmembrane proteins such as POM121 reside in the nuclear pore complex (NPC) and are dispersed throughout the ER network during NE breakdown. It has been shown that POM121 is incorporated into the reforming NE via ER tubules connected to chromatin. It is now proposed that the intrinsic ability of the ER to move between membrane sheets and tubules is used to form the NE (Anderson, 2008). View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. View All» Control: U2OS cell lysate View All» Quality Assurance: Evaluated by Western Blot in U2OS cell lysate.Western Blot Analysis: 1:1,000 dilution of the antibody detected POM121 in 10 µg of U2OS cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurifed rabbit polyclonal containing serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q8K3Z9 View All» Entrez Gene Number: NP_683734 View All» Gene Symbol:
  • POM121A

  • P145

  • NUP121

  • POMZP3
    View All» Alternate Names:
    • POM-121

    • nuclear pore membrane protein 121

    • nuclear envelope pore membrane protein POM 121

    • Nuclear envelope pore membrane protein POM 121A Pore membrane protein of 121 kDa

    • Nucleoporin

    • Nup121
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (By similarity).SUBCELLULAR LOCATION: Nucleus › nuclear pore complex By similarity. Nucleus membrane; Single-pass membrane protein (by similarity). Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Note: Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase (by similarity).DOMAIN: Contains F-X-F-G repeats.PTM: Proteolytically cleaved by caspase-3 during apoptosis (by similarity).SEQUENCE SIMILARITIES: Belongs to the POM121 family. View All» Product Name: Anti-POM121 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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