货号：AB6048

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dynactin subunit 1 Antibody | AB6048 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Dynactin subunit 1 at the coiled coil region. View All» Molecular Weight: ~142 kDa observed.An uncharacterized band appears at ~55 kDa in some lysates. View All» Epitope: Coiled Coil Region View All» Immunogen: KLH-conjugated linear peptide corresponding to the coiled coil region of human Dynactin subunit 1. View All» Background Information: Dynactin is a processivity factor for cytoplasmic dynein. Dynactin is also important in the positioning of the mitotic spindle. Dynactin is involved in the forward movement of the growth cone and is essential for activating the dynein motor complex, which is important in many other cell functions such as mitosis. Dynactin seems to hold the metaphasic centrosome in place to ensure the transition to anaphase. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Ox
  View All» Species Reactivity Note: Demonstrated to react with Human, Rat, and Mouse. Predicted to react with Ox based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Dynactin subunit 1 in rat cerebellum, rat cortex, human cerebellum, and human cortex tissues. View All» Control: Human testis lysate View All» Quality Assurance: Evaluated by Western Blot in human testis lysate.Western Blot Analysis: A 1:5,000 dilution of this antibody detected Dynactin subunit 1 in 10 µg of human testis lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14203 View All» Entrez Gene Number: NP_004073 View All» Gene Symbol: DCTN1 View All» Alternate Names: Dynactin subunit 1150 kDa dynein-associated polypeptideDAP-150Short name=DP-150p135p150-glued View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.SUBUNIT STRUCTURE: Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3. Interacts with FBXL5. Interacts with ECM29. Interacts (via C-terminus) with SNX6. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton. TISSUE SPECIFICTY: Brain.PTM: Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome. INVOLVEMENT IN DISEASE: Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B) [MIM:607641]; also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors. Defects in DCTN1 are the cause of Perry syndrome (PERRYS) [MIM:168605]; also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.SEQUENCE SIMILARITIES: Belongs to the dynactin 150 kDa subunit family.Contains 1 CAP-Gly domain. View All» Product Name: Anti-Dynactin subunit 1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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