货号：AB6055

品牌：Merck Millipore

规格：

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Kinesin-like protein KIF2C View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~81 kDa observed. An uncharacterized band may appear at ~50 kDa in some lysates. Uniprot describes 2 isoforms at ~76 and ~81 kDa. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Kinesin-like protein KIF2C. View All» Background Information: Kinesin-like protein KIF2C (KIF2C), also known as MCAK, is a mitotic centromere-associated kinesin, which belongs to the MCAK/KIF2 subfamily. It is expressed in two isoforms: isoform 2 is found exclusively in the testis; whereas isoform one is widely expressed, in varying levels, in the thymus, testis, small intestine, colon, placenta, spleen, and ovary. Kinesin-like protein KIF2C plays an important role in mitosis; It contains a microtubule tip localization signal (MtLS) motif and is involved in microtubule plus-end depolymerization. By modulating the turnover of microtubules at the kinetochore, kinesin-like protein KIF2C facilitates chromosome segregation, which is critical during mitosis. Kinesin-like protein KIF2C is regulated by the Aurora B kinase. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rat, Bovine, Rhesus Macaque, and Mouse based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analyis: A 1:500 dilution from a representative lot detected Kinesin-like protein KIF2C in A431, HeLa, and NIH/3T3 cells.Note: Kinesin-like protein KIF2C appears concentrated on centromeres at prophase and persists until telophase, after which time the localization disperses. (Wordeman, L., et al. (1995). Journal of Cell Biology. 128(1/2):95-105.) View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Kinesin-like protein KIF2C in 10 µg of K562 cell lysate. View All» Purification Method: Antigen Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q99661 View All» Entrez Gene Number: NP_006836 View All» Gene Symbol:

• KIF2C

• KNSL6
  View All» Alternate Names:
  • Kinesin-like protein KIF2C

  • Kinesin-like protein 6

  • Mitotic centromere-associated kinesin

  • MCAK
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Product Name: Anti-Kinesin-like protein KIF2C View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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