货号：AB6070

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MT1-MMP Antibody, hemopexin domain | AB6070 View All» Replaces: AB8104 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the hemopoxin domain of MT1-MMP. View All» Molecular Weight: ~66 kDa observed View All» Epitope: Hemopoxin Domain View All» Immunogen: Recombinant protein corresponding to the entire hemopexin-like domain of MT1-MMP. View All» Background Information: Matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes degrade components of extracellular matrix (ECM), including collagens, fibronectin, laminin and other glycoproteins. MMPs play an important role in wound healing, apoptosis, development, angiogenesis, cancer metastases, and tissue remodeling. Most MMPs are secreted as inactive proproteins which are cleaved and activated; however, MT1-MMP (MMP-14) is a member of the membrane-type subfamily. Each member of this subfamily has a transmembrane domain suggesting these proteins are expressed at the cell’s surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of ECM components and thought to be an important tool for cellular remodeling of the ECM. It is also involved in endothelial cell migration, and although not fully characterized, MT1-MMP activity appears to modulate endothelial invasion, and formation of capillary tubes during angiogenesis. It also appears to be a factor in monocyte recruitment during inflammation. MT1-MMP also activates MMP-2 protein, an activity involved in tumor invasion. View All» Species Reactivity:

• Human

• Rat

• Horse

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Predicted to react with Horse, Chimpanzee and Rhesus Macaque based on 100% sequence homology. Other homologies: Pig, Bovine, and Canine (98% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:400 dilution of this antibody detected MT1-MMP in human and rat colon tissue. View All» Control: HT-1080 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HT-1080 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected MT1-MMP in 10 µg of HT-1080 cell lysate. View All» Purification Method: Protein A Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P50281 View All» Entrez Gene Number: NP_004986 View All» Gene Symbol: MMP14 View All» Alternate Names:
  • Matrix metalloproteinase-14

  • MMP-14

  • MMP-X1

  • Membrane-type matrix metalloproteinase 1

  • MT-MMP 1

  • MTMMP1

  • Membrane-type-1 matrix metalloproteinase

  • MT1-MMP

  • MT1MMP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.CATALYTIC ACTIVITY: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.COFACTOR: Binds 1 zinc ion per subunit (by similarity). Calcium (by similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (potential). Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.TISSUE SPECIFICITY: Expressed in stromal cells of colon, breast, and head and neck.DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.POST-TRANSLATIONAL MODIFICATION: The precursor is cleaved by a furin endopeptidase (by similarity).SEQUENCE SIMILARITIES: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. View All» Product Name: Anti-MT1-MMP, hemopexin domain View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Purified View All» Host: Rabbit View All»
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