货号：AB7144F

品牌：Merck Millipore

规格：2mL

目录价：￥4138.00

市场价格：￥3517.30

会员价格：￥3310.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fibrinogen Antibody, FITC conjugated | AB7144F View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Prior to conjugation, the antibody was specific for fibrinogen when tested against human plasma by Coomassie Blue R stained double immunodiffusion and immunoelectrophoresis. Undesired immune reactivity has been removed by solid phase immunoadsorption. LABELLING RATIO Fluorescein:antibody molar ratio: 2.8 - 3.3 Absorbance ratio (A493/A276): 0.78 + 0.05 View All» Immunogen: Purified fibrinogen derived from pooled human plasma. View All» Species Reactivity: Human View All» Application Notes: WORKING DILUTION The final working dilution is dependent on the specific assay conditions. However, in fluorescence microscopy good results can be expected with dilutions in the following ranges: 1. Incident light excitation Direct immunofluorescence: 1/10 - 1/80 Indirect immunofluorescence: 1/20 - 1/400 2. Transmitted light excitation Direct immunofluorescence: 1/5 - 1/40 Indirect immunofluorescence: 1/10 - 1/80 View All» Presentation: The antibody is supplied in 20mM Tris, 70mM NaCl, pH 8.0, with 0.1% sodium azide as preservative. View All» Storage Conditions: Store at +2 to +8°C, for up to 6 months, undiluted. Protect from light. WARNING: This reagent contains 0.1% sodium azide as preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water. View All» UniProt Number: P02671 View All» Entrez Gene Number:

• NM_000508.3

• NM_021871.2
  View All» Gene Symbol:
  • FGA

  • MGC119423

  • MGC119425

  • Fib2

  • MGC119422
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunodiffusion

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. View All» UniProt Summary: FUNCTION: SwissProt: P02671 # Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.SIZE: 866 amino acids; 94973 Da SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.SUBCELLULAR LOCATION: Secreted.DOMAIN: SwissProt: P02671 A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.PTM: The alpha chain is not glycosylated. & The alpha chain binds by 2-4 cross-links to the amino end of fibronectin. & About one-third of the alpha chains in the molecules in blood were found to be phosphorylated. & Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon- (gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.DISEASE: SwissProt: P02671 # Defects in FGA are a cause of congenital afibrinogenemia [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations. & Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias. & Defects in FGA are a cause of hereditary renal amyloidosis [MIM:105200].SIMILARITY: Contains 1 fibrinogen C-terminal domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Fibrinogen Antibody, FITC conjugated | AB7144F View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 2 mL View All» Format: FITC View All» Host: Sheep View All»
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