货号：AB747

品牌：Merck Millipore

规格：500UL

目录价：￥5677.00

市场价格：￥4825.45

会员价格：￥4541.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Collagen Type III Antibody | AB747 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody reacts with native and heat denatured (non-reduced) human collagen type III. Cross reactions with other types of collagen under native conditions do occur. There is 10% cross reactivity with human collagen type I, 2% cross reactivity with human collagen type II, and 4% cross reactivity with human collagen type IV and V. There is no cross reactivity with other human plasma proteins under native ELISA conditions. Reactivity under denatured conditions has not been examined. Cross Reactivity Percent Human collagen type I 10% Human collagen type II 2% Human collagen type III 100% Human collagen type IV and V 4% Human plasma proteins do not interfere with binding to collagen. View All» Immunogen: Human placental collagen type III View All» Species Reactivity: Human View All» Application Notes: ELISA 1:3,000 Indirect immunofluorescence on cryostat sections or cultured cells 1:20-1:40 Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended:

• Western Blotting

• Immunohistochemistry (Paraffin)
  View All» Presentation: 500ul containing of 0.15M NaCl, 10 mM sodium phosphate pH 7.5, with 0.1% mannitol and o.1% dextran as stabilizers contains no preservatives. Immunoglobulin fraction was prepared by ammonium sulfate precipitation and chromatography on DEAE-cellulose, of antiserum cross-absorbed over immobilized human serum proteins, immunoglobulins, and collagen types I, II, IV and V. View All» Storage Conditions: Antibody is stable for 12 months from date of receipt when stored at 2-8ºC. Remove any nondispersed aggregates by microcentrifugation prior to use. View All» UniProt Number: P02461 View All» Entrez Gene Number: NM_000090.3 View All» Gene Symbol:
  • COL3A1

  • EDS4A

  • FLJ34534
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunofluorescence
      View All» Entrez Gene Summary: This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish] View All» UniProt Summary: FUNCTION: SwissProt: P02461 # Collagen type III occurs in most soft connective tissues along with type I collagen.SIZE: 1466 amino acids; 138564 Da SUBUNIT: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.DISEASE: SwissProt: P02461 # Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type III (EDS-III) [MIM:130020]; also known as benign hypermobility syndrome. Inheritance is autosomal dominant. EDS is characterized by joint laxity and hyperextensible skin. It is divided into nine different subtypes based on biochemical and clinical variations. & Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type IV (EDS-IV) [MIM:130050]. EDS-IV is the most severe form of the disease, in that it often produces life-threatening consequences, such as rupture of the arteries, bowel, or uterus. A variant form of EDS-IV is Gottron type acrogeria [MIM:201200]. The main characteristics are atrophy and mottled-type hyperpigmentation of the acral skin, resulting in an aged appearance. & Defects in COL3A1 may be a cause of aortic aneurysm [MIM:100070]. Aortic aneurysm consists of a dangerous ballooning of the aorta which is caused by a defect in the artery's wall.SIMILARITY: SwissProt: P02461 ## Belongs to the fibrillar collagen family. & Contains 1 VWFC domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Collagen Type III Antibody | AB747 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Purified View All» Host: Rabbit View All»
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