货号：AB757P

品牌：Merck Millipore

规格：100Ug

目录价：￥5126.00

市场价格：￥4357.10

会员价格：￥4100.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Collagen Type III Antibody | AB757P View All» Replaces: AB757 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: Collagen Type III extracted and purified from rat skin. Antibody shows less than 0.1% reactivity with rat Collagen Type I and rat Elastin with less than 10.0% reactivity with rat Collagen Type V. View All» Specificity: Rat Type III 100% Rat Type I Rat Type V 9% Mouse Type III 9% Human Type I Rat Elastin View All» Species Reactivity: Rat View All» Application Notes: Immunohistochemistry: 1:80 dilution for immunofluorescent staining of frozen rat skin and liver tissues. Radioimmunoassay ELISA: 1:1000 Not recommended for paraffin tissue sections or Western blots. Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended:

• Western Blotting

• Immunohistochemistry (Paraffin)
  View All» Presentation: Affinity purified immunoglobulin. Liquid, containing 0.01M phosphate, 0.09M NaCl, pH 7.2. No preservatives. View All» Storage Conditions: Maintain frozen at -20°C for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P02461 View All» Entrez Gene Number: NM_000090.3 View All» Gene Symbol:
  • COL3A1

  • EDS4A

  • FLJ34534
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Radioimmunoassay

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish] View All» UniProt Summary: FUNCTION: SwissProt: P02461 # Collagen type III occurs in most soft connective tissues along with type I collagen.SIZE: 1466 amino acids; 138564 Da SUBUNIT: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.DISEASE: SwissProt: P02461 # Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type III (EDS-III) [MIM:130020]; also known as benign hypermobility syndrome. Inheritance is autosomal dominant. EDS is characterized by joint laxity and hyperextensible skin. It is divided into nine different subtypes based on biochemical and clinical variations. & Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type IV (EDS-IV) [MIM:130050]. EDS-IV is the most severe form of the disease, in that it often produces life-threatening consequences, such as rupture of the arteries, bowel, or uterus. A variant form of EDS-IV is Gottron type acrogeria [MIM:201200]. The main characteristics are atrophy and mottled-type hyperpigmentation of the acral skin, resulting in an aged appearance. & Defects in COL3A1 may be a cause of aortic aneurysm [MIM:100070]. Aortic aneurysm consists of a dangerous ballooning of the aorta which is caused by a defect in the artery's wall.SIMILARITY: SwissProt: P02461 ## Belongs to the fibrillar collagen family. & Contains 1 VWFC domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Collagen Type III Antibody | AB757P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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