货号：AB763P

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Collagen Type V Antibody | AB763P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: Collagen Type V extracted and purified from human placenta. Antibody shows less than 0.1% reactivity with human Collagen Types I, III, and IV. AB763P also shows 0.1% reactivity with human Fibronectin and mouse Laminin by radioimmunoassay. View All» Specificity: Human collagen type V: 100% Human collagen type I, II, & III: Human collagen type IV: 20% Human fibronectin, albumin, immunoglobulins: View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: 1:40 dilution for immunofluorescent staining of frozen human skin, liver and placenta tissues. Radio Immunoassay ELISA Optimal working dilution must be determined by end user. View All» Presentation: IgG fraction. Liquid View All» Storage Conditions: Maintain frozen at -20°C for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P20908 View All» Entrez Gene Number: NM_000093.3 View All» Gene Symbol:

• COL5A1

• OTTHUMP00000064637
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunofluorescence

  • Radioimmunoassay
    View All» Entrez Gene Summary: This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. View All» UniProt Summary: FUNCTION: SwissProt: P20908 # Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.SIZE: 1838 amino acids; 183560 Da SUBUNIT: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Sulfated on 40% of tyrosines.DISEASE: SwissProt: P20908 # Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type I (EDS-I) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS-I is a connective-tissue disorder characterized by loose-jointedness and fragile, velvety, stretchable, bruisable skin that heals with peculiar 'cigarette-paper' scars. Inheritance is autosomal dominant. & Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type II (EDS-II) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis. Inheritance is autosomal dominant.SIMILARITY: SwissProt: P20908 ## Belongs to the fibrillar collagen family. & Contains 1 laminin G-like domain. & Contains 1 TSP N-terminal (TSPN) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Collagen Type V Antibody | AB763P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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