货号：AB7821

品牌：Merck Millipore

规格：500Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Collagen Type VI Antibody | AB7821 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human collagen type I Human collagen type II Human collagen type III Human collagen type IV Human collagen type V 5% Human collagen type VI 100 % Human fibronectin Human albumin Human immunoglobulin View All» Immunogen: Human placental collagen type VI View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: 1:10-1:40 dilution of reconstitute for indirect immunofluorescent staining of frozen tissue sections. ELISA: 1:10,000 dilution of reconstitute for ELISA on human collagen type VI. Optimal working dilutions must be determined by the end user. View All» Presentation: Pooled antisera was cross-absorbed against immobilized human serum proteins and collagen types IV and V. The IgG fraction was then precipitated with ammonium sulfate and subsequently dialyzed. Lyophilized from 500μL of 10mM Na-phosphate, 150mM NaCl, pH 7.5 with 0.1% mannitol. View All» Storage Conditions: Maintain lyophilized at -20°C for up to 12 months. Reconstitute with 500uL of distilled water or saline. Store reconstitute between 2 and 8°C for up to two months. Remove any insoluble material by microcentrifugation before use. View All» UniProt Number: P12109 View All» Entrez Gene Number: NM_001848.2 View All» Gene Symbol:

• COL6A1

• OPLL
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunohistochemistry
    View All» Entrez Gene Summary: The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. View All» UniProt Summary: FUNCTION: SwissProt: P12109 # Collagen VI acts as a cell-binding protein.SIZE: 1028 amino acids; 108529 Da SUBUNIT: Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.DISEASE: SwissProt: P12109 # Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.SIMILARITY: SwissProt: P12109 ## Contains 3 VWFA domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Collagen Type VI Antibody | AB7821 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 µg View All» Format: Serum View All» Host: Rabbit View All»
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