货号：AB81011

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calpain LP85 and LP82, large subunit View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with the cysteine protease, LP82/LP85-calpain large subunit. The antibody is specific for LP85-calpain and does not react with the other calpain family members (m-calpain, m-calpain, calpain-94, ncl-2, ncl-3, etc.) This antibody recognizes both latent and active LP82 and LP85-calpain; the latent large subunit is 82 kDa and 85 kDa, and the amino terminal truncation at activation yields an approximately 60 kDa and 62 kDa form. View All» Epitope: large subunit View All» Immunogen: Synthetic peptide based on the carboxy-terminal end of the domain-III from LP82-calpain large subunit, based on the rat sequence. View All» Background Information: LP85-calpain, also known as lens specific calpain, is an intracellular, calcium-dependent cysteine protease. LP85-calpain is almost identical to LP82-calpain, only an insert distinguishes them. The calpains have papain-like activity, thus the -pain nomenclature. Unlike m-calpain and m-calpain, which are ubiquitously expressed, LP82 and LP85-calpain were originally identified in rat lens. Like other calpains, the endogenous calpain inhibitor, calpastatin, counters LP82 and LP85. Because of limited distribution and sequence differences, LP82 and LP85-calpains are thought to have different roles than the other calpain family members. View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:1000 for colorimetric substrates or 1:5000 for chemiluminescent substrates (recommended starting concentration). ELISA Immunohistochemistry Immunoprecipitation Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.01M PBS, pH 7.4 with 15mM sodium azide as a preservative and 50% glycerol as a stabilizer. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number:

• O70376

• O08702
  View All» Gene Symbol: CAPN3 View All» Alternate Names: Lens-specific Calpain View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunoprecipitation

  • Western Blotting

  • Immunohistochemistry
    View All» Brand Family: Chemicon View All» Product Name: Anti-Calpain LP85 and LP82, large subunit View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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