货号：AB81016

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-8, N-terminus View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MMP-8, was first described in neutrophils, is a classical type-I collagenase; like MMP-1 it is able to cleave intact type-I collagen at the same site in all three strands. The sequence for MMP-8 is similar to MMP-1, but until recently it was thought to be produced exclusively by neutrophils. MMP-8 has recently been detected in other cell types. MMP-8 is heavily glycosylated, and the zymogen has a mass of 85 kDa. The zymeogen has a mass of 85 kDa. The zymogen is quickly activated to the 64 kDa form, and this breaks down to a cascade of active forms. Antibody AB81016 is made against a synthetic peptide corresponding to the amino terminal end of the human MMP-8 sequence, also known as Collagenase-2, and Neutrophil Collagenase. The antibody binds to MMP-8, but does not cross-react with the other MMP family members. View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to the amino terminal end of human MMP-8. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1000 when using colorimetric substrates; 1:5,000 for chemiluminescent substrates. When used against the reduced protein, antibody AB81016 recognizes bands at 64 kDa, 58 kDa, and a series of further cleaved active forms. MMP-8 is not produced by most cell types; it has been found in PMNL neutrophils, arthritic chondrocytes and gingival fibroblasts. MMP-8 levels in quiescent cells and tissues are minimal, and mitogen stimulation of protein concentration is often needed to visualize the bands. In addition, cell types differ greatly in the quantity of MMP-8 produced. AB81016 is also expected to be effective for immunoprecipitation, immunohistochemistry, and ELISA. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid at 1 mg/mL containing sodium azide and 50% glycerol. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P22894 View All» Entrez Gene Number: NM_002424.1 View All» Gene Symbol:

• MMP8

• PMNL-CL

• MMP-8

• HNC

• CLG1

• EC 3.4.24.34
  View All» Alternate Names: Neutrophil Collagenase; Collagenase 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P22894 # Can degrade fibrillar type I, II, and III collagens.COFACTOR: Binds 3 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 467 amino acids; 53412 Da SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Stored in intracellular granules.TISSUE SPECIFICITY: Neutrophils.DOMAIN: SwissProt: P22894 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-8, N-terminus View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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