货号：AB81023

品牌：Merck Millipore

规格：100Ul

目录价：￥7642.00

市场价格：￥6495.70

会员价格：￥6113.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calpain II Antibody, large subunit | AB81023 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The anti-calpain II antibody recognizes the 80 kDa and 58 kDa forms of Calpain II. It does not cross-react with other calpains. View All» Epitope: large subunit View All» Background Information: Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpain-1 and 2 consist of a common small subunit and a large variable subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF-hand domain IV.Type I calpain requires micromolar amounts of calcium, while type II calpain requires millimolar amounts of calcium. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Application Notes: Western blot: 1:1000 for colorimetric substrates or 1:5000 for chemiluminescent substrates (recommended starting concentration). Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS pH 7.4 containing 0.02% sodium azide, 1% BSA and 50% glycerol as a stabilizer. View All» Storage Conditions: Maintain at -20*C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P17655 View All» Entrez Gene Number: NM_001748.4 View All» Gene Symbol:
  • CAPN2

  • millimolar-calpain

  • M-calpain

  • Millimolar-calpain

  • mCANP

  • FLJ39928

  • CANP2

  • CANPml

  • CANPL2

  • EC 3.4.22.53
    View All» Alternate Names: M-Calpain; Calpain 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P17655 # Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.COFACTOR: Binds 3 calcium ions.SIZE: 700 amino acids; 80009 Da SUBUNIT: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: SwissProt: P17655 ## Belongs to the peptidase C2 family. & Contains 1 calpain catalytic domain. & Contains 3 EF-hand domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Calpain II Antibody, large subunit | AB81023 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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