货号：AB8117

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-7, catalytic domain View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Antibody AB8117 is directed against a synthetic peptide corresponding to the catalytic domain of human MMP-7, also known as matrilysin, PUMP, and uterine metalloproteinase. The immunogen peptide is contained in the catalytic domain of MMP-7, aminoterminal to the zinc site. The antibody binds to MMP-7 but does not cross-react with the other MMP family members. View All» Epitope: catalytic domain View All» Immunogen: Synthetic peptide corresponding to the catalytic domain of human MMP-7, aminoterminal to the zinc site View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1000 when using colorimetric substrates; 1:5,000 for chemiluminescent substrates. When used against the reduced protein, antibody AB8117 recognizes a band at 28 kDa for the zymogen, and 18 kDa for the active enzyme. The antibody recognizes both active and latent5 forms of MMP-7. MMP-7 levels in quiescent cells and tissues is minimal, and stimulation or protein concentration is often needed to visualize the bands. In addition, cell types differ greatly in the quantity of MMP-7 produced. AB8117 is also expected to be effective for immunoprecipitation, immunohistochemistry, and ELISA. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid at 1 mg/mL containing 0.05% sodium azide and 50% glycerol. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P09237 View All» Entrez Gene Number: NM_002423.3 View All» Gene Symbol:

• MMP7

• MPSL1

• matrin

• MMP-7

• PUMP-1

• Matrin

• PUMP1

• EC 3.4.24.23
  View All» Alternate Names: Matrilysin; PUMP; Uterine Metalloproteinase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P09237 # Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 267 amino acids; 29677 Da DOMAIN: SwissProt: P09237 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.SIMILARITY: Belongs to the peptidase M10A family. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-7, catalytic domain View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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