货号：AB8201

品牌：Merck Millipore

规格：

目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Collagen Type IV Antibody | AB8201 View All» Replaces: AB756P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes native Collagen Type IV View All» Molecular Weight: 164 kDa View All» Immunogen: Collagen IV native protein purified from murine sarcoma basement membrane. View All» Isotype: IgG View All» Background Information: Collagen is a long, fibrous structural protein whose function is quite different from the globular proteins such as enzymes. Tough bundles of collagen called collagen fibers are a major component of the extracellular matrix that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. Collagen has great tensile strength, and the main component of fascia, cartilage, ligaments, tendons, bone, and teeth. It strengthens blood vessels and plays a role in tissue development. There are 28 types of collagen described in literature.Collagen Type IV forms the structural integrity of the basement membrane and is present in the placenta and eye lens. It also serves as part of the filtration system in capillaries and the glomeruli of nephron in the kidney. Collagen IV may inhibit endothelial cell proliferation and angiogenesis via mechanisms involving cell surface proteoglycans and the alpha and beta integrins of endothelial cells. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Application Notes: Suggested dilutions:Immunohistochemistry: 1:50-1:500 dilution for formalin-fixed, paraffin-embedded tissues. Recommended pretreatment using citrate buffer, pH 6.0 and high heat epitope retrieval techniques. Optimal working conditions must be determined by end user. View All» Applications Not Recommended: Western Blotting View All» Control: Human intestinal tissue (basement membrane of the lamina propria) View All» Quality Assurance: Routinely evaluated by Immunohistochemistry onparaffin-embedded human intestinal tissue. View All» Purification Method: Protein G chromatography View All» Presentation: Purified in buffer containing 0.02 M Sodium Phosphate; 150 mM NaCl and 0.1% Sodium Azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of shipment. View All» UniProt Number: P02463 View All» Entrez Gene Number: NM_009931.2 View All» Gene Symbol: COL4A1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. View All» UniProt Summary: FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. SUBUNIT: There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. TISSUE: Brain, Eye, Heart, and Placenta View All» Brand Family: Chemicon View All» Product Name: Anti-Collagen Type IV Antibody | AB8201 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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