货号：AB821

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Apolipoprotein C-III Antibody | AB821 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apolipoprotein C-III, Human. Minimum cross reactivity to Apo A-I, A-II, B, C-I, C-II, E and J by ELISA. Negligible non-specific cross reaction with other human serum proteins. View All» Immunogen: Apolipoprotein C-III, synthetic. View All» Species Reactivity: Human View All» Application Notes: Immunoblotting: 1:5,000-1:10,000: Note use purified casein or BSA for blocking reagents only is recommended because commercial food milk prepartation can immunoabsorb-out the antiserum. Apo CIII monomer runs at approximately 8.75kDa, however unless strong denaturing reagents such as 5M guanidine-HCL are used, aggregates of Apo CIII are common resulting in significant larger bands or smears. Immunohistochemistry on paraffin embedded tissue: 1:50-1:200; citrate antigen recovery suggested; simple blocking solutions also recommended. Immunoprecipitation ELISA: 1:4,000-1:8,000 using 1 μg of Apo C-III in standard sandwich. Optimal working dilutions must be determined by end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.125 M Sodium Borate buffer, 0.075 M Sodium Chloride, 0.005 M EDTA, pH 8.0, with 0.01% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for several weeks. For extended storage mix with an equal volume of glycerol, aliquot contents and freeze at -20°C or below for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P02656 View All» Entrez Gene Number: NM_000040.1 View All» Gene Symbol:

• APOC3

• ApoC-III

• Apo-CIII

• APOCIII

• MGC150353
  View All» Alternate Names: ApoCIII View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunoprecipitation

  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. View All» UniProt Summary: FUNCTION: SwissProt: P02656 # Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.SIZE: 99 amino acids; 10852 Da SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.PTM: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.DISEASE:SwissProt: P02656 # Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).SIMILARITY: SwissProt: P02656 ## Belongs to the apolipoprotein C3 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Apolipoprotein C-III Antibody | AB821 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 1 mg View All» Format: Affinity Purified View All» Host: Goat View All»
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