货号：AB8222

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HS1 (14-3-3 tau/theta) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB8222 recognizes the N-terminal of HS1. View All» Molecular Weight: 75 kDa View All» Epitope: N-Terminus View All» Immunogen: Recombinant protein. View All» Background Information: HS1 (14-3-3 tau/theta), the leukocyte-specific homologue of cortactin, regulates F-actin in vitro and is tyrosine phosphorylated in response to TCR ligation but its role in controlling actin dynamics and lymphocyte activation has not been fully understood. It is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple cell signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preferences for it’s different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 tau/theta is primarily expressed in T-cells but also occurs at lower levels in the brain, heart, pancreas placenta and kidneys. Elevated levels of 14-3-3 tau/theta are observed in amyotrophic lateral sclerosis. 14-3-3 tau/theta also binds BCR/Abl, bacterial effector protein Tir, yes-associated protein and the FSH receptor. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Reactivity with other species has not been determined. View All» Control: Jurkat Cell Lysate. View All» Quality Assurance: Routinely tested on Jurkat cell lysate. View All» Presentation: Serum with 0.05% NaN3 View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: P14317 View All» Entrez Gene Number: NP_005326.2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. SUBUNIT: Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (Probable). Cytoplasm (Probable). Mitochondrion (Probable). TISSUE SPECIFICITY: Expressed only in tissues and cells of hematopoietic origin. DEVELOPMENTAL STAGE: Expressed in early stage of myeloid and erythroid differentiation. PTM: Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells. SIMILARITY: Contains 4 cortactin repeats. SIMILARITY: Contains 1 SH3 domain. View All» Product Name: Anti-HS1 (14-3-3 tau/theta) View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Ascites View All» Host: Mouse View All»