货号：AB8990

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LASP-1 Antibody | AB8990 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Lasp-1. View All» Immunogen: Recombinant human LASP-1. View All» Background Information: Lasp-1 is an actin-binding scaffolding protein that is overexpressed in 8-12% of breast cancers and is correlated to increased incidences of metastasis. Lasp-1 localizes to newly forming focal adhesions and membrane ruffles during cell migration (Lin, 2004). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500 (2.0 μg/mL). Optimal working dilutions must be determined by end user. View All» Presentation: Protein A purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain at 2-8ºC in undiluted aliquots for up to one year from date of receipt. View All» UniProt Number: Q14847 View All» Entrez Gene Number: NM_006148.1 View All» Gene Symbol:

• LASP1

• LASP-1

• MLN50

• Lasp-1
  View All» Alternate Names: Lim, Actin, and SH3 Domain Protein 1; MLN50 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization. View All» UniProt Summary: FUNCTION: SwissProt: Q14847 # Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).SIZE: 261 amino acids; 29717 Da SUBUNIT: Interacts with F-actin (By similarity).SUBCELLULAR LOCATION: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the F-actin rich cortical cytoskeleton (By similarity).PTM: Phosphorylated (By similarity).SIMILARITY: SwissProt: Q14847 ## Contains 1 LIM zinc-binding domain. & Contains 2 nebulin repeats. & Contains 1 SH3 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-LASP-1 Antibody | AB8990 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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