货号：AB9094

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sodium Pump (Na+ pump (Na+-K+-ATPase)) α 2 Isoform Antibody | AB9094 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with Sodium Pump (Na+ pump (Na+-K+-ATPase)) alpha 2 isoform. The antibody does not cross react with other Na+-K+-ATPase alpha isoforms. View All» Immunogen: Synthetic peptide. View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:2,000-1:4,000 for brain and 1:1,000-1:2,000 for muscle. The antibody recognizes a specific band at ~100 kDa. Heat the sample to 37°C in standard Laemmli for 30 minutes (don't boil). Boiling causes some sodium pump heteromers to clench together giving a band at ~150 kDa. Suggested dilution buffer is TBST with 1% BSA containing a preservative. Suggested gel percentage is 7.5%. Immunoprecipiation: see Journal of Biological Chemistry (2004) 279:2885-2893. Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: Brain, muscle, nerves, fat. View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P50993 View All» Entrez Gene Number: NM_000702.2 View All» Gene Symbol:

• ATP1A2

• FHM2

• MGC59864

• KIAA0778

• MHP2

• +K

• Na

• EC 3.6.3.9
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. View All» UniProt Summary: FUNCTION: SwissProt: P50993 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.SIZE: 1020 amino acids; 112265 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DISEASE: SwissProt: P50993 # Defects in ATP1A2 are the cause of familial hemiplegic migraine 2 (FHM2) [MIM:602481]. Familial hemiplegic migraine is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. & Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age.SIMILARITY: SwissProt: P50993 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Sodium Pump (Na+ pump (Na+-K+-ATPase)) α 2 Isoform Antibody | AB9094 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: All neurons View All» Format: Serum View All» Host: Rabbit View All»
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