货号：AB9167

品牌：Merck Millipore

规格：

目录价：￥4785.00

市场价格：￥4067.25

会员价格：￥3828.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GABA B Receptor R1 Antibody | AB9167 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes GABA B Receptor R1. View All» Immunogen: Synthetic peptide from the N-terminal extracellular domain of human GABA B Receptor R1. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry on paraffin embedded tissue sections. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide. View All» Storage Conditions: Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9UBS5 View All» Entrez Gene Number:

• NM_001470.1

• NM_021903.1

• NM_021904.1

• NM_021905.1
  View All» Gene Symbol:
  • GABBR1

  • dJ271M21.1.1

  • GABBR1-3

  • GABAB(1e)

  • GABABR1

  • hGB1a

  • dJ271M21.1.2

  • Gb1

  • GPRC3A

  • GABA-B-R1
    View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants. View All» UniProt Summary: FUNCTION: SwissProt: Q9UBS5 # Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.COFACTOR: Calcium. Required for high affinity binding to GABA.SIZE: 961 amino acids; 108320 Da SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. & Isoform 1E: Secreted (Probable).TISSUE SPECIFICITY: Highly expressed in brain and weakly in heart, small intestine and uterus. Mostly expressed in granular cell and molecular layer for isoform 1A and in Purkinje cells form isoform 1B. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.DOMAIN: SwissProt: Q9UBS5 Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably play a role in the specificity for G-protein coupling.SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. & Contains 2 Sushi (CCP/SCR) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-GABA B Receptor R1 Antibody | AB9167 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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