货号：AB9206

品牌：Merck Millipore

规格：1EA

目录价：￥5820.63

市场价格：￥4947.54

会员价格：￥4656.50

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DARPP-32 Antibody, phosphoThr34 | AB9206 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes DARPP-32 phosphorylated at threonine 34 . View All» Molecular Weight: ~32 kD View All» Epitope: phosphoThr34 View All» Immunogen: Synthetic peptide from DARPP-32, phosphoThr34. View All» Modifications: Phosphorylation View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:1,000. The antibody recognizes the ~32 kD DARPP-32 protein phosphorylated at Thr34 protein in rat caudate lysate prepared from caudate slices that had been incubated in the absence and presence of forskolin. The labeling by the antibody to DARPP-32 Thr34 is markedly increased by the forskolin treatment. Optimal working dilutions must be determined by the end user. View All» Control: Cultured primary neurons, rat brain lysate and human breast adenocarcinoma View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg per mL BSA with 50% glycerol. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: Q9UD71 View All» Entrez Gene Number:
  • NM_032192.2

  • NM_181505.2
    View All» Gene Symbol:
    • PPP1R1B

    • DARPP32

    • DARPP-32

    • FLJ20940
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9UD71 # Inhibitor of protein-phosphatase 1.SIZE: 204 amino acids; 22963 Da SUBCELLULAR LOCATION: Cytoplasm.PTM: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein. & Phosphorylation of Thr-34 is required for activity (By similarity).SIMILARITY: SwissProt: Q9UD71 ## Belongs to the protein phosphatase inhibitor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-DARPP-32 Antibody, phosphoThr34 | AB9206 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Target / Localization: GABAergic neurons in CNS; Medium spiny neurons View All» Format: Affinity Purified View All» Host: Rabbit View All»
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