货号：AB9260

品牌：Merck Millipore

规格：500UL

目录价：￥5109.00

市场价格：￥4342.65

会员价格：￥4087.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ki-67 Antibody | AB9260 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Ki-67 View All» Molecular Weight: Predicted: 359 kDa. MW may be observed at ~345 or 395 kDa View All» Immunogen: Synthetic peptide from human Ki-67 View All» Background Information: Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and mouse. Expected to react with rat based on sequence homology. View All» Application Notes: Immunocytochemistry: Confolcal fluorescent analysis of A431 cells using AB9260 rabbit pAB. Actin filaments were labeled with Alexa Fluor 488 -Phalloidin. Nuclear is stained with DAPI. (Nuclear staining).Western Blot Analysis: A previous lot of this antibody was used in western blot.Optimal working dilutions must be determined by the end user. View All» Control: Positive Control: Breast carcinoma, lymph node tissue, normal tonsil. View All» Quality Assurance: Immunohistochemistry(paraffin): Representative lot data.This antibody was used on formalin fixed, paraffin embedded tissue at 1:300 dilution for 10 minutes at room temperature. Staining of formalin-fixed tissues requires boiling of tissues in 10 mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes. View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 10 mM PBS, pH 7.4 containing BSA and sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P46013 View All» Entrez Gene Number: NM_002417.3 View All» Gene Symbol:
  • MKI67

  • KIA

  • Ki-67
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P46013 # Thought to be required for maintaining cell proliferation.SIZE: 3256 amino acids; 358694 Da SUBUNIT: Binds through the FHA domain to MKI67IP.SUBCELLULAR LOCATION: Nucleus. Note=Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.DEVELOPMENTAL STAGE: Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected.SIMILARITY: SwissProt: P46013 ## Contains 1 FHA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Ki-67 Antibody | AB9260 View All» Concentration: 0.2 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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