货号：AB9274-200UL

品牌：Merck Millipore

规格：200UL

目录价：￥10539.00

市场价格：￥8958.15

会员价格：￥8431.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sodium Channel Nav1.8 Antibody, pain | AB9274-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Nav1.8 (SNS, SCN10A, PN3) View All» Immunogen: Synthetic peptide from rat Nav1.8 (Accession Q63554). The immunogen sequence is 14/15 residues identical in mouse and 7/15 residues identical in human. View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:200 using ECL on rat DRG lysate. Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y5Y9 View All» Entrez Gene Number: NM_006514.2 View All» Gene Symbol:

• SCN10A

• PN3

• Nav1.8

• SNS

• hPN3
  View All» Alternate Names: SNS, SCN10A, PN3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Voltage-gated sodium channels are integral membrane glycoproteins that are responsible for the initial rising phase of action in most excitable cells. They are composed of a large alpha subunit that may be associated with one or more smaller beta subunits. Sodium channels can be differentiated by their primary structure, kinetics, and relative sensitivity to the neurotoxin tetrodotoxin (TTX). Sodium channels, particularly those with TTX-resistant currents, have been found to accumulate in the region of peripheral nerve injury and may be important in chronic pain. SCN10A encodes a TTX-resistant channel that is restricted to the peripheral sensory nervous system (Rabert et al., 1998 [PubMed 9839820]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9Y5Y9 # This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms (By similarity).SIZE: 1956 amino acids; 220566 Da SUBUNIT: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, TCTEL1 and PDZK3. Interacts with proteins such as FSTL1, PRX, TCTEL1, PDZK3, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). Note=It can be translocated to the extracellular membrane through association with S100A10 (By similarity).TISSUE SPECIFICITY: Expressed in the dorsal root ganglia and sciatic nerve.DOMAIN: SwissProt: Q9Y5Y9 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.PTM: Ubiquitinated by NEDD4L; which promotes its endocytosis (By similarity).SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Sodium Channel Nav1.8 Antibody, pain | AB9274-200UL View All» Concentration: 0.8 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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