货号：AB9298

品牌：Merck Millipore

规格：50UL

目录价：￥4131.00

市场价格：￥3511.35

会员价格：￥3304.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MARCKS Antibody, Complete sequence | AB9298 View All» Replaces: AB5427 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes MARCKS. View All» Epitope: Complete sequence View All» Immunogen: Full length recombinant rat MARCKS. View All» Species Reactivity: Rat View All» Application Notes: Immunoblotting: 1:1,000 using rat brain extract (colormetric; higher dilutions may be used with ECL). The antibody reacts with the 70-85 kDa (depending on species) MARCKS protein. The suggested dilution buffer is TBS containing 0.05% Tween-20. Suggested blocking buffer is 5% non-fat dry milk. Suggested transfer membrane is PVDF-Immobilon. Suggested gel percentage is 8%. Overnight incubation with the antibody is recommended. Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: Neonatal rat brain extract. MARCKS is heat and acid resistant. Heat or acid-treated supernatants from crude tissue or cell homogenates are good sources to analyze MARCKS content by immunoblot. View All» Presentation: Semi-purified immunoglobulin. Liquid in 120 mM NaCl, 25 mM Tris-HCl, pH 7.3 containing 0.01% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P29966 View All» Entrez Gene Number: NM_002356.5 View All» Gene Symbol:

• MARCKS

• MACS

• 80K-L

• FLJ14368

• PRKCSL

• phosphomyristin

• MRACKS

• PKCSL

• FLJ90045
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. View All» UniProt Summary: FUNCTION: SwissProt: P29966 # MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.SIZE: 332 amino acids; 31555 Da PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.SIMILARITY: SwissProt: P29966 ## Belongs to the MARCKS family. View All» Brand Family: Chemicon View All» Product Name: Anti-MARCKS Antibody, Complete sequence | AB9298 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Target / Localization: Soma View All» Format: Purified View All» Host: Rabbit View All»
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