货号：AB9374

品牌：Merck Millipore

规格：

目录价：￥3993.00

市场价格：￥3394.05

会员价格：￥3194.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LR11 Antibody | AB9374 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes LR11 [low-density lipoprotein receptor relative with 11 binding repeats]. View All» Immunogen: Synthetic peptide from human LR11. View All» Species Reactivity: Human View All» Application Notes: Immunoblotting: 0.5-1.0 μg/mL on HEK cells transfected with LR11. The antibody reacts with the ~250 kD LR11 protein. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q92673 View All» Entrez Gene Number: NM_003105.3 View All» Gene Symbol:

• SORL1

• LR11

• LRP9

• SorLA

• SORLA

• SorLA-1

• gp250
  View All» Alternate Names: low-density lipoprotein receptor relative with 11 binding repeats View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. View All» UniProt Summary: FUNCTION: SwissProt: Q92673 # Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction.SIZE: 2214 amino acids; 248441 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).TISSUE SPECIFICITY: Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to Ref.1, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to Ref.2, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.PTM: The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.SIMILARITY: SwissProt: Q92673 ## Contains 5 BNR repeats. & Contains 1 EGF-like domain. & Contains 6 fibronectin type-III domains. & Contains 11 LDL-receptor class A domains. & Contains 5 LDL-receptor class B repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-LR11 Antibody | AB9374 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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