货号：AB9556

品牌：Merck Millipore

规格：

目录价：￥4645.00

市场价格：￥3948.25

会员价格：￥3716.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GODZ Antibody | AB9556 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes GODZ (Golgi-specific DHHC zinc finger protein, zDHHC3, zf-DHHC3). View All» Immunogen: Synthetic peptide from mouse GODZ. View All» Background Information: The Golgi-specific DHHC zinc finger protein (GODZ) is a widely expressed, highly conserved integral membrane protein. GODZ mRNA is found in many tissues; however, in brain the protein is detected concentrated and asymmetrically distributed within neuronal Golgi complex only. The interaction of GODZ with specific GABAA and GluRalpha receptor subunits in vitro and likely palmitoylation function suggests a role for this novel protein in receptor trafficking in vivo. Since GODZ is restricted to Golgi and receptors such as GABAA do not normally accumulate there, no long-term colocalization is likely to be found. The palmitoylation of GABAA and other diverse neuronal proteins, including GPCRs, by a transient GODZ protein complex represents a reversible posttranslational modification key for regulated trafficking in neurons. View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Immunoblotting: 0.5-2.0 μg/mL using ECL on rat brain lysate. Reacts with the ~27 kDa GODZ protein. Additional bands of ~40 and ~75 kDa may be seen depending on sample and antibody concentration used. Immunocytochemistry: 0.5-2.0 μg/mL on cultured neurons. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q9NYG2 View All» Entrez Gene Number: NM_016598.1 View All» Gene Symbol:
  • ZDHHC3

  • ZNF373

  • LOC51304

  • DHHC-3

  • GODZ

  • EC 2.3.1.-
    View All» Alternate Names: Golgi-specific DHHC zinc finger protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: SwissProt: Q9NYG2 # Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity).SIZE: 327 amino acids; 37338 Da SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein (By similarity).DOMAIN:SwissProt: Q9NYG2 The DHHC domain is required for palmitoyltransferase activity (By similarity).PTM: Autopalmitoylated (By similarity).SIMILARITY: Belongs to the DHHC palmitoyltransferase family. & Contains 1 DHHC-type zinc finger. View All» Brand Family: Chemicon View All» Product Name: Anti-GODZ Antibody | AB9556 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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