货号：AB9600

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuropilin-1 Antibody | AB9600 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Neuropilin-1. The immunogen sequence has low homology with neuropilin-2. View All» Immunogen: Synthetic peptide from the N-terminal CUB domain of human neuropilin-1. View All» Species Reactivity: Human View All» Species Reactivity Note: It is expected that the antibody will also react with rat and mouse. View All» Application Notes: Western blot: 1:500 on transfected COS-7 cells. The antibody reacts with the ~130 kDaprotein. The suggested antibody diluent is PBS containing 5% non-fat milk and 0.04%Tween 20. View All» Presentation: Affinity purified immunoglobulin in PBS containing 50% glycerol, 1 mg/mL BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O14786 View All» Entrez Gene Number:

• NM_001024628.1

• NM_001024629.1

• NM_003873.4
  View All» Gene Symbol:
  • NRP1

  • neuropilin-1

  • DKFZp781F1414

  • VEGF165R

  • NRP

  • DKFZp686A03134

  • CD304
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: O14786 # The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.SIZE: 923 amino acids; 103120 Da SUBUNIT: Heterodimer with NRP2 (Probable). Binds PLXNB1.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.SIMILARITY: SwissProt: O14786 ## Belongs to the neuropilin family. & Contains 2 CUB domains. & Contains 2 F5/8 type C domains. & Contains 1 MAM domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Neuropilin-1 Antibody | AB9600 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Plasma membrane View All» Format: Affinity Purified View All» Host: Rabbit View All»
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