货号：AB9714

品牌：Merck Millipore

规格：

目录价：￥4154.00

市场价格：￥3530.90

会员价格：￥3323.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RAGE Antibody | AB9714 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: RAGE (Receptor for Advanced Glycosylation End Products). View All» Molecular Weight: ~48-50kDa View All» Immunogen: Synthetic peptide from human RAGE, amino acids 39-58 (KGAPKKPPQRLEWKLNTGRT). View All» Isotype: IgG View All» Background Information: RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration. View All» Species Reactivity:

• Bovine

• Human

• Mouse
  View All» Application Notes: Western blot: 1:1,000-1:2,500 on extracts from bovine and mouse lungs and in HeLa cells expressing human soluble RAGE. Flow cytometry: 1 μg/mL per million cells using a PE conjugated second antibody. ELISA: 1:10,000-1:50,000 against the immunogen peptide. Optimal working dilutions must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in PBS with 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q15109 View All» Entrez Gene Number:
  • NM_001136.3

  • NM_172197.1
    View All» Gene Symbol:
    • AGER

    • RAGE

    • MGC22357
      View All» Alternate Names: Receptor for Advanced Glycosylation End Products View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Flow Cytometry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: Q15109 # Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.SIZE: 404 amino acids; 42803 Da SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Endothelial cells.SIMILARITY: SwissProt: Q15109 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-RAGE Antibody | AB9714 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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