货号：AB9718

品牌：Merck Millipore

规格：

目录价：￥4376.00

市场价格：￥3719.60

会员价格：￥3500.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DJ-1/PARK7 Antibody | AB9718 View All» Replaces: AB9212 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes DJ-1/PARK7, Mr ~22 kDa. View All» Molecular Weight: ~22 kDa View All» Epitope: a.a. 89-100 View All» Immunogen: KLH-conjugated synthetic corresponding to a.a. 89-100 of human DJ-1/PARK7. View All» Background Information: DJ-1, also known as PARK7 (Parkinson disease (autosomal recessive, early onset) 7) is a member of the peptidase C56 family of proteins, but is not known to exhibit proteolytic activity. It acts as a positive regulator of androgen receptor-dependent transcription. It also functions as a redox-sensitive chaperone, as a sensor for oxidative stress, and it protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. DJ-1/PARK7 is characterized by onset before 40 years, slow progression and initial good response to levodopa. Defects in DJ-1/PARK7 influence susceptibility to amyotrophic lateral sclerosis-parkinsonism/ dementia complex type 2, also called Guam disease. DJ-1/PARK7 also has demonstrated cell-growth promoting activity and transforming activity. Two transcript variants encoding the same protein have been identified for this gene. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, rat. Not tested on other species. View All» Application Notes: Immunocytochemistry View All» Control: Human testis or murine brain tissue lysate. View All» Quality Assurance: Routinely evaluated by Western Blot Analysis View All» Purification Method: Peptide affinity chromatography View All» Presentation: Purified by peptide affinity chromatography. Supplied at 1.0 mg/ml in 100 μL of 0.1M Tris-Glycine (pH7.4) 15 mM NaCl, with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution. View All» UniProt Number: Q99LX0.1 View All» Entrez Gene Number: NM_001123377 View All» Gene Symbol:
  • DJ-1

  • DJ1

  • FLJ27376

  • FLJ34360

  • FLJ92274

  • OTTHUMP00000001348

  • OTTHUMP00000001349

  • OTTHUMP00000001350

  • OTTHUMP00000001351
    View All» Alternate Names:
    • Oncogene DJ1

    • Parkinson disease (autosomal recessive, early onset) 7

    • Parkinson disease protein 7

    • protein DJ-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitivechaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION:Acts as a positive regulator of androgen receptor-dependent transcription. May function as a redox-sensitiv chaperone and as a sensor for oxidative stress. Prevents aggregation of SNCA. Protects neurons against oxidative stress and cell death. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity (By similarity).SUBUNIT: Homodimer. Binds EFCAB6/DJBP and PIAS2. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (Bysimilarity). Note=Associated with mitochondria in some cells, particularly after oxidative stress (By similarity).PTM:Sumoylated on Lys-130 by PIAS2 or PIAS4; which is essential for cell-growth promoting activity and transforming activity (By similarity).SIMILARITYBelongs to the peptidase C56 family View All» Product Name: Anti-DJ-1/PARK7 Antibody | AB9718 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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