货号：AB9742

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-14-3-3 σ Antibody | AB9742 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: 14-3-3 sigma. By Western blot the antibody recognizes the ~30 kDa protein. View All» Immunogen: Synthetic peptide from the N-terminal area of sheep 14-3-3 sigma. View All» Background Information: Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's. The 14-3-3 sigma antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease. View All» Species Reactivity:

• Bovine

• Chicken

• Human

• Mouse

• Rat

• Sheep
  View All» Application Notes: Western blot: 1:3000 Optimal working dilutions must be determined by end user. View All» Purification Method: Serum View All» Presentation: Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P31947 View All» Entrez Gene Number: NM_006142.3 View All» Gene Symbol:
  • SFN

  • YWHAS

  • HME1

  • stratifin

  • Stratifin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P31947 # p53-regulated inhibitor of G2/M progression.SIZE: 248 amino acids; 27774 Da SUBUNIT: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway.TISSUE SPECIFICITY: Present mainly in tissues enriched in stratified squamous keratinising epithelium.SIMILARITY: SwissProt: P31947 ## Belongs to the 14-3-3 family. View All» Brand Family: Chemicon View All» Product Name: Anti-14-3-3 σ Antibody | AB9742 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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