货号：AB9772-200UL

品牌：Merck Millipore

规格：

目录价：￥8479.00

市场价格：￥7207.15

会员价格：￥6783.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SK1 (KCA2.1) Antibody | AB9772-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes SK1 (K_CA2.1, Small conductance Ca²⁺-activated K⁺ Channel 1, SKCa1, KCNN1). View All» Immunogen: Purified peptide from amino acids 75-93 of rat SK1. View All» Species Reactivity: Rat View All» Species Reactivity Note: The immunogen sequence is 17 of 19 amino acids identical in mouse and 12 of 19 amino acids identical in human. View All» Application Notes: Western blot: 1:200 using ECL on rat brain cortex. Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Control: Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number:

• P70606

• Q92952
  View All» Gene Symbol:
  • SK1

  • KCNN1
    View All» Alternate Names: Small conductance Ca²⁺-activated K⁺ Channel 1, SKCa1, KCNN1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. View All» UniProt Summary: FUNCTION: SwissProt: Q92952 # Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).SIZE: 543 amino acids; 59987 Da SUBUNIT: Hetero-oligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: Q92952 ## Belongs to the potassium channel KCNN family. View All» Brand Family: Chemicon View All» Product Name: Anti-SK1 (KCA2.1) Antibody | AB9772-200UL View All» Concentration: 0.6 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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