货号：AB9776-50UL

品牌：Merck Millipore

规格：

目录价：￥4680.00

市场价格：￥3978.00

会员价格：￥3744.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sloβ4 Antibody | AB9776-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes sloβ4 (KCNMB4, Ca²⁺-activated K⁺ channel β subunit 4, BK_Ca β subunit 4). View All» Immunogen: Purified peptide from amino acids 2-17 of rat sloβ4 View All» Species Reactivity: Rat View All» Species Reactivity Note: The immunogen sequence is identical in human and mouse. View All» Application Notes: Western blot: 1:200 using ECL on rat brain membranes. Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number:

• Q9ESK8

• Q86W47
  View All» Gene Symbol:
  • KCNMB4

  • KCMB4

  • BKbeta4

  • SLObeta4
    View All» Alternate Names: KCNMB4, Ca²⁺-activated K⁺ channel β subunit 4, BK_Ca β subunit 4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. View All» UniProt Summary: FUNCTION: SwissProt: Q86W47 # Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.SIZE: 210 amino acids; 23949 Da SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.DOMAIN:SwissProt: Q86W47 Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.PTM: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics. & N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.SIMILARITY: Belongs to the KCNMB family. MISCELLANEOUS: Treatment with okadaic acid reduces its effect on KCNMA1. View All» Brand Family: Chemicon View All» Product Name: Anti-Sloβ4 Antibody | AB9776-50UL View All» Concentration: 0.6 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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