货号：AB9784

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Kv1.3 Antibody | AB9784 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Kv1.3 (KCNA3). View All» Molecular Weight: 62 kDa View All» Immunogen: Highly purified peptide from human Kv1.3. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1 μg/mL using ECL. Recognizes approximately a 62 kDa protein band on CHO K1 cell line expressing hKv1.3. View All» Control: 125 7mu;g of lyophilized control antigen. The stock solution of the antigen can be made up using 12.5 μL of sterile distilled water. For negative control, in Western Blotting, preincubate 10 μg of purified peptide with 1 μg of antibody in a small volume for 1-2 hours at 37°C; centrifuge at maximum speed for 15 minutes, then carefully remove all but 10 μL of the solution (allows the antigen-antibody pellet not to be taken by mistake) and use the removed supernatant for the analysis. View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.1M Glycine / 0.2M Tris buffer solution pH 7.8 containing 0.02% sodium azide View All» Storage Conditions: Maintain material at -20°C for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P22001 View All» Entrez Gene Number: NM_002232.3 View All» Gene Symbol:

• KCNA3

• HLK3

• HuKIII

• HPCN3

• Kv1.3

• MK3

• HUKIII

• HGK5

• PCN3

• KV1.3
  View All» Alternate Names: KCNA3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. View All» UniProt Summary: FUNCTION: SwissProt: P22001 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.SIZE: 523 amino acids; 58304 Da SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DOMAIN: SwissProt: P22001 The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. & The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Kv1.3 Antibody | AB9784 View All» Concentration: 100 μg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 25 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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