货号：AB9828-50UL

品牌：Merck Millipore

规格：

目录价：￥4680.00

市场价格：￥3978.00

会员价格：￥3744.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Kv11.2 Antibody | AB9828-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Kv11.2 (erg2, Voltage-gated K⁺ channel subfamily H member 6, KCNH6, ether-a-go-go channel 2). View All» Immunogen: Purified peptide from amino acids 185-198 of human K_v11. View All» Isotype: IgG View All» Species Reactivity: Rat View All» Species Reactivity Note: The immunogen sequence is identical in chicken and 13 of 14 amino acids identical in mouse. View All» Application Notes: Western blot: 1:200 using ECL on rat brain lysate and rat cortex lysate. Immunohistochemistry on rat brain sections. Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Control: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9H252 View All» Entrez Gene Number:

• NM_030779.2

• NM_173092.1
  View All» Gene Symbol:
  • KCNH6

  • erg2

  • ERG2

  • HERG2

  • Kv11.2
    View All» Alternate Names: erg2, KCNH6, ether-a-go-go channel 2, Voltage-gated K⁺ channel subfamily H member 6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q9H252 # Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.SIZE: 994 amino acids; 109925 Da SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimers with KCNH2/ERG1 and KCNH7/ERG3 (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in prolactin-secreting adenomas.DOMAIN:SwissProt: Q9H252 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.SIMILARITY: Belongs to the potassium channel family. H (Eag) subfamily. & Contains 1 cyclic nucleotide-binding domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 1 PAS (PER-ARNT-SIM) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Kv11.2 Antibody | AB9828-50UL View All» Concentration: 0.75 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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