货号：AB9834

品牌：Merck Millipore

规格：50UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Tyrosine Kinase Receptor C View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: trkC [Neurotrophin-3 growth factor receptor; tyrosine kinase receptor C]. All four forms of the TrkC receptor are expected to be detected by this antibody. The immunogen sequence was chosen to avoid cross reactivity with trkA or trkB. View All» Immunogen: Extracellular domain of the recombinant human receptor expressed in mammalian cells. View All» Background Information: The mammalian Trk family of receptor tyrosine kinases consists of three principle transmembrane proteins. The receptors can be activated by one or more of four neurotrophins - NGF, BDNF, NT3 and NT4. Each of the four members of the TrkC family, expressed by alternative splicing, serves as a receptor for NT-3, with some evidence for endogenous activation also by NGF. These neurotrophins regulate biological responses such as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells primarily, but several other cell types have been shown to express the TrkC receptor. The receptor has also been demonstrated on many tumors of neuronal origin. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Results of immunohistochemistry in the dorsal root ganglion have been described by Chen. C., et al., Neurochemical Research (1996) 21(7):809-814.. View All» Purification Method: Serum View All» Presentation: Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative. View All» Storage Conditions: Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability. View All» UniProt Number: Q16288 View All» Entrez Gene Number:
  • NM_001007156.1

  • NM_001012338.1

  • NM_002530.2
    View All» Gene Symbol:
    • NTRK3

    • TRKC

    • gp145(trkC)

    • Trk-C

    • GP145-TrkC

    • EC 2.7.10.1
      View All» Alternate Names: trkC View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. View All» UniProt Summary: FUNCTION: SwissProt: Q16288 # Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.SIZE: 839 amino acids; 94428 Da SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.PTM: Ligand-mediated auto-phosphorylation.SIMILARITY: SwissProt: Q16288 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Tyrosine Kinase Receptor C View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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