货号：AB9846

品牌：Merck Millipore

规格：

目录价：￥4926.00

市场价格：￥4187.10

会员价格：￥3940.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Synapsin I (Ser549) Antibody | AB9846 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Synapsin I, phospho Serine 549. The antibody recognizes a protein doublet of ~78 kDa corresponding to Synapsin I, phospho Serine 549 in lysates from rat brain. The immunolabeling is completely eliminated by treatment with lambda-Ptase. View All» Immunogen: Synthetic peptide of amino acids surrounding the phosphoSerine 549 site of rat Synapsin I. View All» Modifications: Phosphorylation View All» Species Reactivity: Rat View All» Species Reactivity Note: The immunogen has 100% homology with human, mouse, non-human primate, bovine and canine. View All» Purification Method: Immunoaffinity purified View All» Presentation: Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/mL BSA and 50% glycerol. View All» Storage Conditions: Maintain at -20degC in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer. View All» UniProt Number: P17600 View All» Entrez Gene Number:

• NM_006950.3

• NM_133499.2
  View All» Gene Symbol:
  • SYN1

  • SYN1a

  • Synapsin-1

  • SYNI

  • SYN1b
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. View All» UniProt Summary: FUNCTION: SwissProt: P17600 # Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.SIZE: 705 amino acids; 74111 Da SUBUNIT: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity).SUBCELLULAR LOCATION: Cell junction, synapse.PTM: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE:SwissProt: P17600 # Defects in SYN1 are a cause of X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders [MIM:300491].SIMILARITY: SwissProt: P17600 ## Belongs to the synapsin family. View All» Brand Family: Chemicon View All» Product Name: Anti-phospho-Synapsin I (Ser549) Antibody | AB9846 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Presynaptic View All» Format: Affinity Purified View All» Host: Rabbit View All»
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