货号：AB9888

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-KvLQT1 Antibody | AB9888 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: KvLQT1 (KCNQ1). The antibody reacts with the ~70 kDa protein. Higher molecular weight bands may be seen depending on sample used. View All» Immunogen: Synthetic peptide. View All» Species Reactivity:

• Chicken

• Frog
  View All» Species Reactivity Note: Other species have not yet been tested. It is expected that the antibody will react with other vertebrates due to similarity of the immungen peptide. The immunogen sequence shares 11 of 16 amino acids similarity with rat and mouse. View All» Application Notes: Western blot: 1:300-1:3,000. The antibody reacts with the ~70 kDa protein. Higher molecular weight bands may be seen depending on sample used. Immunohistochemistry: 1:300-1:3,000 Optimal working dilutions must be determined by end user. View All» Purification Method: Serum View All» Presentation: Liquid View All» Storage Conditions: Maintain at frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P51787 View All» Entrez Gene Number:
  • NM_181797.1

  • NM_000218.2

  • NM_181798.1
    View All» Gene Symbol:
    • KCNQ1

    • JLNS1

    • ATFB1

    • SQT2

    • KCNA8

    • LQT

    • WRS

    • Kv1.9

    • KVLQT1

    • RWS

    • Kv7.1

    • KCNA9

    • LQTS

    • FLJ26167

    • LQT1
      View All» Alternate Names: KCNQ1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: P51787 # Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.SIZE: 676 amino acids; 74699 Da SUBUNIT: Heteromultimer with KCNE1 (MinK) or KCNE3 (MiRP2).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.DOMAIN: SwissProt: P51787 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.DISEASE: SwissProt: P51787 # Defects in KCNQ1 are the cause of long QT syndrome type 1 (LQT1) [MIM:192500]; also known as Romano-Ward syndrome (RWS). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. LQT1 inheritance is an autosomal dominant. & Defects in KCNQ1 are a cause of Jervell and Lange-Nielsen syndrome (JLNS) [MIM:220400]. JLNS is an autosomal recessive cardio-auditory syndrome characterized by a prolonged QT interval in the electrocardiogram and congenital deafness. & Defects in KCNQ1 are the cause of atrial fibrillation type 1 (ATFB1) [MIM:607554]. ATFB is characterized by rapid and irregular activation of the atrium. ATFB causes thromboembolism, tachycardia-mediated cardiomyopathy, heart failure and ventricular arrhythmia. & Defects in KCNQ1 are the cause of short QT syndrome type 2 (SQT2) [MIM:609621]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.SIMILARITY: Belongs to the potassium channel family. KQT subfamily.MISCELLANEOUS: Mutagenesis experiments were carried out by expressing in Xenopus oocytes or COS-7 cells KCNQ1 mutants either individually (homomultimers) or in combination with both wild-type KCNQ1 (mut/wt homomultimers) and minK (heteromultimers). View All» Brand Family: Chemicon View All» Product Name: Anti-KvLQT1 Antibody | AB9888 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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