货号：AB9906

品牌：Merck Millipore

规格：100UL

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-QKI-6 Antibody | AB9906 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Trade Name: Chemicon (Millipore) View All» Specificity: QKI-6 (Quaking Protein). The antibody recognizes the ~38 kDa protein. View All» Immunogen: Synthetic peptide from mouse QKI-6. View All» Background Information: QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Control: Positive Control: Glial cells, astrocytes and oligodendrocytes. View All» Purification Method: Serum View All» Presentation: Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q96PU8 View All» Entrez Gene Number:
  • NM_006775.1

  • NM_206853.1

  • NM_206854.1

  • NM_206855.1
    View All» Gene Symbol:
    • QKI

    • DKFZp586I0923

    • Hqk

    • QK3

    • QK

    • HKQ

    • HqkI
      View All» Alternate Names: Quaking Protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q96PU8 # RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).SIZE: 341 amino acids; 37671 Da SUBUNIT: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).TISSUE SPECIFICITY: Expressed in the frontal cortex of brain.PTM: Methylated by PRMT1 (By similarity). & Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).DISEASE: SwissProt: Q96PU8 # May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms such as isoform 6, are frequently down-regulated in schizophrenic patients. & Deletion of the QKI gene may play a role in astrocytic tumors.SIMILARITY: SwissProt: Q96PU8 ## Contains 1 KH domain. View All» Brand Family: Chemicon View All» Product Name: Anti-QKI-6 Antibody | AB9906 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Host: Rabbit View All»
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