货号：AB9918

品牌：Merck Millipore

规格：

目录价：￥3978.00

市场价格：￥3381.30

会员价格：￥3182.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glucocorticoid Receptor Antibody | AB9918 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 86kDa View All» Epitope: AA D2 – P400 View All» Immunogen: Recombinant human glucocorticoid receptor View All» Background Information: The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. View All» Species Reactivity: Human View All» Application Notes: Western Blot: 1:5000 View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Raw rabbit serum with 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C for up to 12 months from date of receipt. View All» UniProt Number: P04150 View All» Entrez Gene Number: NP_000167 View All» Gene Symbol:

• GCCR

• GCR

• GR

• GRL
  View All» Alternate Names: GR Nuclear receptor subfamily 3 group C member 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P04150 # Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.SIZE: 777 amino acids; 85659 Da SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding.SIMILARITY: SwissProt: P04150 # Belongs to the nuclear hormone receptor family. NR3 subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Glucocorticoid Receptor Antibody (AB9918) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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