货号：AB9983

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tyrosine Hydroxylase Antibody | AB9983 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # AB9983 recognizes the C-terminus of Tyrosine Hydroxylase View All» Molecular Weight: ~ 58 kDa View All» Epitope: C-terminus View All» Immunogen: Recombinant protein View All» Background Information: Tyrosine Hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Mouse and Rat. Reactivity with other species has not been determined. View All» Application Notes: Immunohistochemistry: 1:100 working dilutions were used on rat and mouse brain (paraffin embedded tissue). View All» Control: Rat Brain lysate View All» Purification Method: Antigen affinity purified View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3 View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P07101 View All» Entrez Gene Number: NP_000351.2 View All» Gene Symbol: TYH View All» Alternate Names:
  • Tyrosine 3-hydroxylase

  • tyrosine 3-monooxygenase

  • tyrosine hydroxylase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Plays an important role in the physiology of adrenergic neurons.CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.COFACTOR: Fe2+ ion.ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity.PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.INVOLVEMENT IN DISEASE: Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.SEQUENCE SIMILARITIES: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. View All» Product Name: Anti-Tyrosine Hydroxylase Antibody | AB9983 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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