货号：AB9987

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-BLM (Ser434) Antibody | AB9987 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes phosphorylated BLM at Ser434. View All» Molecular Weight: 160 kDa View All» Epitope: Ser434of BLM protein View All» Immunogen: KLH-conjugated linear peptide corresponding to phosphorylated human BLM at Ser434. View All» Modifications: Phosphorylation View All» Background Information: The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. Bloom syndrome protein has been shown to interact with CHEK1, Replication protein A1, Werner syndrome ATP-dependent helicase, RAD51L3, Ataxia telangiectasia mutated,]RAD51, XRCC2, Flap structure-specific endonuclease 1H2AFX, TP53BP1, P53, TOP3A, MLH1and CHAF1A. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Mouse and rat (69%). View All» Control: Nocodazole treated and untreated HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in nocodazole treated and untreated HeLa cell lysate.Western Blot Analysis: 1 µg/ml of this antibody detected BLM on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P54132 View All» Entrez Gene Number: NP_000048 View All» Gene Symbol:

• BLM

• BLAP18

• BS

• RECQ2

• RECQL2

• RECQL3

• RMI2
  View All» Alternate Names:
  • Bloom syndrome 1

  • Bloom syndrome protein

  • Bloom syndrome, RecQ helicase-like

  • DNA helicase, RecQ-like type 2

  • RecQ protein-like 3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. SUBUNIT STRUCTURE: Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ubiquitinated FANCD2. Interacts with RMI complex. Interacts directly with RMI1 component of RMI complex. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1.INVOLVEMENT IN DISEASE: Defects in BLM are the cause of Bloom syndrome (BLM) [MIM:210900]. BLM is an autosomal recessive disorder characterized by proportionate pre- and postnatal growth deficiency, sun-sensitive telangiectatic hypo- and hyperpigmented skin, predisposition to malignancy, and chromosomal instability.SEQUENCE SIMILARITIES: Belongs to the helicase family. RecQ subfamily.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.Contains 1 HRDC domain. View All» Product Name: Anti-phospho-BLM (Ser434) View All» Concentration: .25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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