货号：ABC102

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CCN1/CYR61 Antibody | ABC102 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the CTCK domain of: CCN1/CYR61 View All» Molecular Weight: ~53 kDa observed. The calculated molecular weight of this protein is 42 kDa, but can be observed at higher molecular weights due to glycosylation. A degradation fragment may be observed at ~15 kDa in some lysates. (Rother et al., 2010) View All» Epitope: CTCK domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the CTCK domain of human CCN1/CYR61. View All» Background Information: CCN1 (cysteine-rich 61 or CYR61), a ubiquitous angiogenic factor, is a member of the CNN family, which is also comprised of CTGF, WISP-1, WISP-2, and WISP-3. It is a multidomain protein, containing one each of CTCK, IGFBP, TSP type-1, and VWFC domains. CCN1 is associated with the extracellular matrix and functions as a ligand for integrin receptors. It is expressed in response to growth factor stimulation, and mediates various cellular processes, including cell adhesion, migration, proliferation, angiogenesis, extracellular-matrix remodeling, and placental development. Previous studies have indicated that it may also play a role in wound healing by influencing the expression of genes required for this process, such as TIMP1, PAI-1, VEGA-A, VEGA-C, MMP1, MMP3, and uPA. CCN1 has also been implicated in breast cancer. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Chimpanzee based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:200 dilution from a representative lot detected CCN1/CYR61 in human kidney tissue. View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected CCN1/CYR61 in 10 µg of NIH/3T3 cell lysate. View All» Purification Method: Antigen Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00622 View All» Entrez Gene Number: NP_001545 View All» Gene Symbol:
  • CYR61

  • CCN1

  • GIG1

  • IGFBP10
    View All» Alternate Names:
    • Protein CYR61

    • CCN family member 1

    • Cysteine-rich angiogenic inducer 61

    • Insulin-like growth factor-binding protein 10

    • IBP-10

    • IGF-binding protein 10

    • IGFBP-10

    • Protein GIG1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Product Name: Anti-CCN1/CYR61 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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